HMM gene prediction using two genomic sequences of close organisms (as Human and Mouse)

The program can be used if DNA sequences of homologous genomic regions of two similar organisms, such as Human and mouse, are available.

Ab initio gene prediction programs usually correctly predict significant fraction of exons in a gene, but they often assemble gene in incorrect way: combine several genes or split one gene into several, skip exons or include false exons. Using sequences of two organisms can significantly improve accuracy of exact gene finding, taking into account that Human genome draft sequence and Mouse genomic sequence provide a lot of homologous sequences.