Recognition of human PolII promoter region and start of transcription

TSSG is the most accurate mammalian promoter prediction program.

Algorithm predicts potential transcription start positions by linear discriminant function combining characteristics describing functional motifs and oligonucleotide composition of these sites. TSSG uses promoter.dat file with selected factor binding sites (TFD, Ghosh,1993) developed by Dan Prestridge to calculate the density of functional sites as in J.Mol.Biol.,1995,249,923-932.